Application of genetics I

Basically browing water for whom has not bad biology foundation.

Genetic diseases diagnosis:
Amniocentesis
Chorionic villus sampling

Gene therapy
Germ-line gene therapy:

• defective allele is replaced or supplemented in the fertilised egg.
• All cell of the organism will develop normally.
• Long term effect.

Somatic-cell gene therapy:

• target just affected tissues
• Not evident in gamete,no pass in future generation
• Need to repeat periodically

-Example introducing healthy CRTR gene into lung epithelial cell

• use harmless virus(adenovirus) as a vector, to transfer gene into host cell, OR
  
• wrap the gene in lipid molecules(liposome) to enable it to pass through membranes of lung epithelial cells.